AppAway - 60

Key Points:

AppAway

2-Amino-3-Phenylpropanoic acid acts as an appetite suppressant by administrating the release of an intestinal hormone-cholecystokinin(CCK)-which signals the brain to feel satiated after eating.

Cholecystokinin (CCK) is released as food enters the stomach. It tells the digestion to slow down and then gives the message to the brain that you are 'full', one's appetite naturally decreases. This takes around 20 minutes.

Appaway is a convenient Appetite suppressant. If you take Appaway 20 minutes to one hour before eating a meal, you'll notice that you'll feel full faster-so you don't fill up on extra calories that you don't need! And not only that, you'll stay full longer

Alpha-Amino-p-Hydroxyhydrocinnamic acid (Alpha-Amino-p-Hydroxy-hydro-cinnamic acid) plays several important roles in metabolism, it is a precursor to the thyroid hormones and other important biological regulators like the catecholammes. Thyroid hormones stimulate a number of metabolic processes. The catecholammes - dopamine, nor-epinephrine and epinephrine are derived from Alpha-Amino-p-Hydroxy-hydro-cinnamic acid.

The product of Alpha-Amino-p-Hydroxy-hydro-cinnamic acid hydrocilation is dopa, once formed, dopa under goes decarboxcilation to give dopamine which serves as a subtrate for the formation of nor-epinephrine, which in turn is methylated to give epinephrine. The release of fat from adipose tissue is controlled hormonally, to meet the needs for energy generation. In adipose tissue the primary hormonal effect are mediated by epinephrine which is one of the catecholammes resulting from Alpha-Amino-p-Hydroxy-hydro-cinnamic acid metabolism. (Biochemistry - C.K Mathews and K.E. van Holde) The primary hormone promoting glycogenolysis in muscle is epinephrine

Alpha-Amino-p-Hydroxy-hydro-cinnamic acid(Appitex) is a precursor for several important neurotransmitters such as dopamine, epinephrine, and norepinephrine. Such neurotransmitters are important for controlling mood, depression, cognitive performance, concentration, and stress.

Alpha-Amino-p-Hydroxy-hydro-cinnamic acid(Appitex) has also been associated with offsetting fatigue, heightened alertness, and increasing metabolic rate.

Alpha-Amino-p-Hydroxy-hydro-cinnamic acid(Appitex) is an effective way to safely boost the metabolism for over-weight and obese individuals. It influence the production of thyroid hormone levels, specifically thyroxine, a hormone which regulates the bodies metabolic rate. Alpha-Amino-p-Hydroxy-hydro-cinnamic acid(Appitex) is also important for the production of neurotransmitters dopamine, epinephrine, and norepinephrine; all of which have been shown to successfully suppress appetite.

 

Key info- Summary

AppAway:

is a convenient Appetite suppressant.

plays several important roles in metabolism.

boost the metabolism

is a precursor to the thyroid hormones. Thyroid hormones stimulate a number of metabolic processes.

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PACKAGE INSERT
AppAway

AppAway has not been evaluated by the Medicine Control Council. AppAway is not intended to diagnose, treat, cure or prevent any disease.

SCHEDULING STATUS
To be allocated by Council upon registration.

PROPRIETARY NAME (and dosage form)
AppAway- (hard gelatine capsules)

COMPOSITION:
Each daily dosage contains:

Active ingredients:

2-amino-3-phenylpropanoic acid (L-Phenylalanine)
Alpha-Amino-p-Hydroxy-hydro-cinnamic acid (L-Tyrosine)

Inactive ingredients:
Magnesium Stearate
Talc USP
Aerosil

PHARMACOLOGICAL CLASSIFICATION:
D41 Complementary medicine not otherwise specified

PHARMACOLOGICAL ACTION:
Pharmacodynamic and Pharmacokinetic properties
2-Amino-3-Phenylpropanoic acid (L-Phenylalanine) acts as an appetite suppressant by administrating the release of an intestinal hormone-cholecystokinin(CCK)-which signals the brain to feel satisfied after eating. Alpha-Amino-p-Hydroxyhydrocinnamic acid (Alpha-Amino-p-Hydroxy-hydro-cinnamic acid) plays several important roles in metabolism, it is a precursor to the thyroid hormones and other important biological regulators like the catecholammes. Thyroid hormones stimulate a number of metabolic processes. The catecholammes - dopamine, nor-epinephrine and epinephrine are derived from Alpha-Amino-p-Hydroxy-hydro-cinnamic acid. The product of Alpha-amino-p-Hydroxy-hydro-cinnamic acid hydroxylation is dopa, once formed, dopa under goes decarboxcilation to give dopamine which serves as a substrate for the formation of nor-epinephrine, which in turn is methylated to give epinephrine. The release of fat from adipose tissue is controlled hormonally, to meet the needs for energy generation. In adipose tissue the primary hormonal effect are mediated by epinephrine which is one of the catecholammes resulting from Alpha-Amino-p-hydroxy-hydro-cinnamic acid metabolism.

2-amino-3-phenylpropanoic acid (L-Phenylalanine)
Adsorption: The metabolite, tyrosine slightly increased in concentration in plasma, for as long as three hours after ingestion of L-phenylalanine.
Metabolism: L-phenylalanine is hydroxylated to L-tyrosine.
Elimination: Urinary excretion occurs for a small amount of the dose of L-phenylalanine.

Alpha-Amino-p-Hydroxy-hydro-cinnamic acid (L-Tyrosine)
Tyrosine is a nonessential amino acid found in soy products, chicken, fish, almonds, avocados, bananas, dairy products, lima beans, pumpkin seeds, and sesame seeds. Tyrosine is produced from endogenous phenylalanine, which is an essential amino acid.
Metabolism: According to secondary sources, L-tyrosine is broken down via an alpha-ketoglutarate-dependent transamination through tyrosine transaminase to para-hydroxyphenylpyruvate. The next oxidation step is catalyzed by p-hydroxyphenylpyruvate-dioxygenase via oxidation, resulting in a splitting off of CO2homogentisate (2,5-dihydroxyphenyl-1-acetate); the aromatic ring of homogentisate is then split using an additional dioxygenase; homogentisate-oxygenase and maleylacetoacetate are created with the incorporation of O2. Fumarylacetate is created via maleylacetoacetate-cis-trans-isomerase with glutathione as a coenzyme. Fumarylacetoacetate is then split via fumarylacetoacetate-hydrolase through the addition of a water molecule. Fumarate, also a metabolite of the citric acid cycle, and acetoacetate (3-ketobutyroate) are released.

INDICATIONS:
AppAway is used as a workout supplement that helps with weight management in conjunction with a kilojoule restricted diet.

CONTRAINDICATIONS:
AppAway is contraindicated in:
Known hypersensitivity to L-Phenylalanine and L-Tyrosine.
Known or suspected pregnancy (see PREGNANCY AND LACTATION).
Breastfeeding (see PREGNANCY AND LACTATION).
Should not be used in conjunction with other appetite suppressants, Mono-Amin-Oxidase (MAO inhibitors) and anti-depressants and patients suffering from phenylketonuria.
Children under 12 years of age.

WARNINGS AND SPECIAL PRECAUTIONS:
Use with caution in patients with uncontrolled high blood pressure. Patients with other heart conditions should consult their health practitioner before using AppAway.
Patients with Parkinson's disease should consult with their health practitioner before taking AppAway(see INTERACTIONS WITH AppAway). Use with caution in patients with glaucoma and patients using thyroid supplementation (see INTERACTIONS WITH AppAway)

INTERACTIONS WITH AppAway
L-phenylalanine and non-selective MAOI drugs might increase the risk of hypertensive crisis.
L-phenylalanine and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson's disease.
Tyrosine is a precursor to thyroid hormone and might boost levels. These drugs include levothyroxine, liothyronine and thyroxine.

PREGNANCY AND LACTATION:
Safety and efficacy in pregnancy and lactation have not been established and the administration of AppAway during pregnancy is therefore contraindicated. If pregnancy occurs during the use of AppAway, further intake should be stopped. AppAway should not be used during breastfeeding.

DOSAGE AND DIRECTIONS FOR USE:
Take 1-2 capsules in the morning and 1-2 capsules in the afternoon 30 minutes before meals or as prescribed by a healthcare practitioner. Do not exceed the recommended dosage.

CHILDREN
Use not recommended.

SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Nervous system disorders:
Tachycardia, thirst, tremors, urinary retention.
Gastrointestinal disorders:
Gastrointestinal or abdominal discomfort, diarrhoea and nausea.
Skin and subcutaneous tissue disorders:
Skin irritation or rash.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF TREATMENT:
Treatment is symptomatic and supportive. There is no specific antidote.

IDENTIFICATION:
White and red capsules that contain white powder.

PRESENTATION:
The capsules are packed into securitainers containing 60 capsules. Blisters contain 30 capsules.

STORAGE INSTRUCTIONS:
Store below 25 ˚C, in a dry, dark place. Keep in original packaging.
KEEP OUT OF REACH OF CHILDREN

REGISTRATION NUMBER:
To be allocated by Council upon registration.

STATEMENT
This medicine has not been evaluated by the Medicines Control Council. This medicine is not
intended to diagnose, treat, cure or prevent any disease.

NAME AND BUSINESS ADDRESS FOR THE HOLDER OF THE CERTIFICATE OF REGISTRATION
California Pharmaceuticals (Pty) Ltd, 179 Edison Crescent, Hennopspark X7, Centurion, 0157
www.cntlabs.co.za

DATE OF PUBLICATION OF PACKAGE INSERT:
Will be allocated by Council upon registration

Company Reg No: 2002/023566/07

Comments

Company MAXXmarketing GmbH

DISCLAIMER:

All CNT Labs supplements are suitable for individuals 18 years and older, unless otherwise stated on the product. Should not be used by pregnant / lactating women without firstly consulting a healthcare practitioner. Individuals suffering from a medical condition or taking any prescription or over-the counter medication should consult their healthcare practitioner before using these products. Discontinue if you experience any adverse reaction. Products have not been evaluated by SAHPRA and do not intend to diagnose, treat, cure or prevent any form of illness or disease and should not replace any medication.

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